SPINK1 Is a Susceptibility Gene for Fibrocalculous Pancreatic Diabetes in Subjects from the Indian Subcontinent
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چکیده
منابع مشابه
SPINK1 is a susceptibility gene for fibrocalculous pancreatic diabetes in subjects from the Indian subcontinent.
Fibrocalculous pancreatic diabetes (FCPD) is a secondary cause of diabetes due to chronic pancreatitis. Since the N34S variant of the SPINK1 trypsin inhibitor gene has been found to partially account for genetic susceptibility to chronic pancreatitis, we used a family-based and case-control approach in two separate ethnic groups from the Indian subcontinent, to determine whether N34S was associ...
متن کامل[Fibrocalculous pancreatic diabetes].
Fibrocalculous pancreatic diabetes (FCPD) is a unique form of diabetes secondary to chronic pancreatitis seen in developing countries of the world associated with either overt protein-calorie malnutrition or, more likely, with deficiency of certain micronutrients. FCPD affects young individuals and runs an aggressive course to reach the endpoints of diabetes, pancreatic calculi and exocrine pan...
متن کاملFibrocalculous Pancreatic Diabetes (FCPD) in India
FCPD is a unique form of diabetes secondary to tropical calcific pancreatitis. FCPD usually affects the poorer strata of society and patients are lean and often frankly malnourished. The hall-marks of the disease are the occurrence of pain in abdomen in childhood and pancreatic calculi associated with dilatation of the pancreatic duct and fibrosis of the gland in adolescence. Diabetes sets in b...
متن کاملFibrocalculous pancreatic diabetes in patient residing in the Mediterranean region.
A 40-year old male residing in the Mediterranean region and afflicted with chronic pancreatitis and diabetes is presented. This is a case of chronic calcific non-alcoholic pancreatitis with characteristic intraductal calculi on abdominal X-ray. Five years following the initial episode of pancreatitis, the patient developed insulin-requiring diabetes mellitus. This case accords with the criteria...
متن کاملPrevalence of cardiac autonomic neuropathy in Asian Indian patients with fibrocalculous pancreatic diabetes
BACKGROUND It was formerly believed that since fibrocalculous pancreatic diabetes (FCPD) is a secondary form of diabetes, specific diabetic complications were uncommon. This is no longer considered to be true. Our objective was to study the prevalence and pattern of cardiac autonomic neuropathy (CAN) in patients with FCPD. MATERIALS AND METHODS A cross-sectional study on consecutive male pati...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2002
ISSN: 0002-9297
DOI: 10.1086/342731